Palliative treatment

Palliative treatment has been studied in 3 papers since 2023: 3 observational studies in people. The newest paper, Aug 11, 2025: “Survival and risk factors for death in older adults with primary head and neck cancer: A retrospective observational cohort study”.

Exposure

3 papers study it2 findingsUpdated

See all 3

“The palliative treatment group had worse overall survival outcomes compared to curative (hazard ratio (HR) of 7.96, p < 0.001).”
Frailty and the Survival Outcomes of Patients With Laryngeal Squamous Cell CancerHead & neck2024doi:10.1002/hed.27951

None of its findings points the other way.

  • 2 independent labs in 2 countries
  • Funder: UKRI | Medical Research Council
  • Humans3

What did studies of Palliative treatment find?

1

Studies of Palliative treatment measured 1 outcome; the most studied are overall survival (1 study).

Overall survival

downin humans1HR 7.96

1 study
  1. Palliative treatment impairs overall survival in humans (HR 7.96, p < 0.001).

    “The palliative treatment group had worse overall survival outcomes compared to curative (hazard ratio (HR) of 7.96, p < 0.001).”

    Humanslaryngeal squamous cell cancer

    Frailty and the Survival Outcomes of Patients With Laryngeal Squamous Cell Cancer

    Head & neck

What is Palliative treatment linked with?

1

Studies link Palliative treatment with 1 measure, most often frailty (1 study).

Frailty

upin humans1

1 study
  1. Frailty is associated with palliative treatment in humans (16.4% vs 4.7%).

    “Frail patients were more likely to receive palliative intent treatment (16.4% vs. 4.7%; p = 0.003).”

    Humansmucosal head and neck SCC

    Differences in clinical presentation and treatment decisions between frail and not-frail head and neck cancer patients

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

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