mFI-5

Biomarker4 papers5 findings

Humans4

Effects

1

Overall survival

no changein humans1

1 study

mFI-5 has no effect on overall survival in humans.
Humansin patients undergoing surgery for OSCCn = 127
Modified 5-Item Frailty Index Is Associated with Postoperative Delirium but Not Survival in Patients Undergoing Surgery for Oral Squamous Cell Carcinoma · Diagnostics (Basel, Switzerland) · 13 Aug 2026

Associations

4

Mortality discrimination

upin humans1

1 study

mFI-5 predicts mortality discrimination in humans (AUC 0.757).
Humansafter pancreatoduodenectomy for periampullary lesions
The Modified Frailty Index Predicts Failure-to-Rescue Mortality After Pancreatoduodenectomy: A Comparison of the 11-Item and 5-Item Versions · World journal of surgery · 23 Sep 2026

90-day mortality

upin humans1OR 2.8

1 study

mFI-5 predicts 90-day mortality in humans (OR 2.8, 95% CI 1.4-5.6).
Humansafter pancreatoduodenectomy for periampullary lesions
The Modified Frailty Index Predicts Failure-to-Rescue Mortality After Pancreatoduodenectomy: A Comparison of the 11-Item and 5-Item Versions · World journal of surgery · 23 Sep 2026

Grip strength

downin humans1

1 study

Grip strength is associated with mFI-5 in humans (r = -0.464, P < .001).
Humansdegenerative cervical myelopathyn = 94
Low handgrip strength is associated with impaired gait and dexterity in patients with degenerative cervical myelopathy: A cross-sectional study · Medicine · 21 Aug 2026

Grip strength →

Postoperative delirium

upin humans1OR 3.07

1 study

mFI-5 raises the risk of postoperative delirium in humans (adjusted OR 3.07 (95% CI 1.08-8.60, p = 0.035)).
Humansin patients undergoing surgery for OSCC, adjusted for age ≥65 years and sexn = 127
Modified 5-Item Frailty Index Is Associated with Postoperative Delirium but Not Survival in Patients Undergoing Surgery for Oral Squamous Cell Carcinoma · Diagnostics (Basel, Switzerland) · 13 Aug 2026

Postoperative delirium →

Latest

10

Journal of Clinical MedicineHumans28 Sep

Preoperative Frailty-Inflammation Phenotypes and Early Functional and Patient-Reported Recovery After Head-and-Neck Oncologic Reconstruction: An Exploratory Prospective Single-Center Cohort Study

World Journal of SurgeryHumans24 Sep

The Modified Frailty Index Predicts Failure-to-Rescue Mortality After Pancreatoduodenectomy: A Comparison of the 11-Item and 5-Item Versions

The Journal of ArthroplastyHumans23 Sep

Modified 6-Factor Frailty Index Enhances Risk Stratification in Revision Total Hip Arthroplasty

Cancer MedicineHumans16 Sep

The FINE Index: A Frailty- and Immunonutrition-Based Nomogram for Survival in Geriatric Breast Cancer: A Retrospective Study

The Journal of ArthroplastyHumans1 Sep

The Risk Analysis Index is Superior to the Modified 5-Factor Frailty Index for Predicting 30-Day Mortality Following Arthroplasty for Femoral Neck Fractures

Journal of Neurosurgery SpineHumans28 Aug

Mortality risk after traumatic fractures in autofused spines from ankylosing spondylitis or DISH: age may matter more than treatment

Bones and joints

DiagnosticsHumans27 Aug

Modified 5-Item Frailty Index Is Associated with Postoperative Delirium but Not Survival in Patients Undergoing Surgery for Oral Squamous Cell Carcinoma

Research SquareHumansPreprint22 Aug

The Prognostic Value of the Modified Frailty Index-5 Combined with Albumin in Patients Undergoing the Bentall Procedure: A Retrospective Cohort Study

MedicineHumans22 Aug

Low handgrip strength is associated with impaired gait and dexterity in patients with degenerative cervical myelopathy: A cross-sectional study

AHA Scientific Sessions 2025 AbstractHumans3 Nov

The Prognostic Value of Modified Frailty Index in Complications and Survival Following Percutaneous Coronary Interventions: A Data-Driven Approach