Esophagectomy
Esophagectomy has been studied in 11 papers since 2017: 11 observational studies in people. The newest paper, Oct 15, 2025: “Brief preoperative frailty predicts postoperative adverse outcomes in older patients with radical esophageal cancer surgery”.
“BMD decreased annually after esophagectomy.”
None of its findings points the other way.
- 3 independent labs in 1 country
- Funder: Japan Society for the Promotion of Science
- Humans11
What did studies of Esophagectomy find?
2Studies of Esophagectomy measured 2 outcomes; the most studied are bone mineral density (1 study) and global health status and quality of life (1).
Bone mineral density
downin humans1
1 study
Bone mineral density
downin humans1
Esophagectomy decreases bone mineral density in humans (from 134.2 HU before surgery to 102.4 HU at 5 years).
“BMD decreased annually after esophagectomy.”
Humanspostoperative5 years
Long-term changes in bone mineral density in postoperative patients with esophageal cancer
Annals of gastroenterological surgery
Global health status and quality of life
no changein humans1
1 study
Global health status and quality of life
no changein humans1
Esophagectomy has no effect on global health status and quality of life in humans.
“Global health status and quality of life were similar in both groups (P = 0.245)”
HumansDisease-free esophageal cancer survivors compared with matched noncancer controlsover 6 months postesophagectomymalesn = 25
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
What is Esophagectomy linked with?
4Studies link Esophagectomy with 4 measures, most often E-PASS (1 study), osteoporosis (1) and moderate and vigorous physical activity (1).
E-PASS
downin humans1
1 study
E-PASS
downin humans1
Esophagectomy is associated with E-PASS in humans.
“E-PASS score was significantly lower in the group that underwent surgery compared to those who received chemotherapy, radiation, or palliative treatment.”
Humansstage II/III esophageal cancer
Indication and Perioperative Management for Esophagectomy in Elderly Patients of Esophageal Cancer
Kyobu geka. The Japanese journal of thoracic surgery
Osteoporosis
upin humans1
1 study
Osteoporosis
upin humans1
Esophagectomy raises the risk of osteoporosis in humans (from 25.9% before surgery to 60.4% at 5 years).
“Esophageal cancer survivors are more likely to develop osteoporosis after esophagectomy”
Humanspostoperative5 years
Long-term changes in bone mineral density in postoperative patients with esophageal cancer
Annals of gastroenterological surgery
Moderate and vigorous physical activity
downin humans1
1 study
Moderate and vigorous physical activity
downin humans1
Esophagectomy is associated with moderate and vigorous physical activity in humans.
“time spent in moderate (P < 0.001) and vigorous (P < 0.001) intensity physical activity compared with controls.”
HumansDisease-free esophageal cancer survivors compared with matched noncancer controlsover 6 months postesophagectomymalesn = 25
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
Fitness
downin humans1
1 study
Fitness
downin humans1
Esophagectomy is associated with fitness in humans.
“Esophageal cancer survivors demonstrated significantly lower fitness (P < 0.001)”
HumansDisease-free esophageal cancer survivors compared with matched noncancer controlsover 6 months postesophagectomymalesn = 25
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
Funding
1 grant since 2021Japan Society for the Promotion of ScienceJP¥3.5m