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Paeonol

Intervention

1 paper3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

3

SIRT1

upin cells1

1 study

  1. Paeonol activates SIRT1 in cells.

    “paeonol binds directly to SIRT1 and then activates the SIRT1/P53/TRF2 pathway”

    Cellsin vitro

    Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway

    Molecules (Basel, Switzerland)4 Jan 2024

More on SIRT1

Cellular senescence

downin cells1

1 study

  1. Paeonol inhibits cellular senescence in cells.

    “paeonol binds directly to SIRT1 and then activates the SIRT1/P53/TRF2 pathway to inhibit VSMCs senescence.”

    Cellsin vivo and in vitro

    Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway

    Molecules (Basel, Switzerland)4 Jan 2024

More on Cellular senescence

Atherosclerosis

downin animals1

1 study

  1. Paeonol decreases atherosclerosis.

    “protective effects of paeonol on VSMCs senescence, and its potential activity in inhibiting the progression of atherosclerosis in vivo and in vitro.”

    Animalsin vivo and in vitro

    Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway

    Molecules (Basel, Switzerland)4 Jan 2024

More on Atherosclerosis

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