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P53-SPECIFIC senolytic peptide

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 5 more
  • Animals1

Outcomes

1

Chronic pain

downin mice1

1 study

  1. P53-SPECIFIC senolytic peptide decreases chronic pain in mice.

    “Pain hypersensitivity was reversed by repeated intrathecal administration of a p53‐specific senolytic peptide, only in male mice and only many months after injury.”

    Animalsmany months after nerve injurymales

    Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence

    The Journal of clinical investigation15 Apr 2022

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