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P38 inhibitor-primed mesenchymal stem cell microvesicles + P38 inhibitor-primed mesenchymal stem cell exosomes

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Department of Biotechnology, Government of West Bengal and 1 more
  • Animals1

Outcomes

1

HSC engraftment

upin mice1

1 study

  1. P38 inhibitor-primed mesenchymal stem cell microvesicles + P38 inhibitor-primed mesenchymal stem cell exosomes increase HSC engraftment in mice.

    “Infusing a combination of pMVs- and pExos-expanded HSCs as a composite graft resulted in significantly higher HSC engraftment”

    Animalscomposite graft

    Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function

    Artificial cells, nanomedicine, and biotechnology10 Mar 2025

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