P21 shRNA
1 paper3 findings
- 1 lab in 1 country
- Funder: Calgary Foundation
- Animals1
Outcomes
3CDKN1A
downin mouse cells1−80% reduction
1 study
CDKN1A
downin mouse cells1−80% reduction
P21 shRNA decreases CDKN1A in mouse cells (~80% reduction).
“In vitro, p21 shRNA achieved ~80% reduction in p21 mRNA and increased G2M phase cells.”
Cellslentiviral transduction
p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair
FASEB journal : official publication of the Federation of American Societies for Experimental Biology21 Apr 2026
P21+ cells
downin mice1
1 study
P21+ cells
downin mice1
P21 shRNA decreases p21+ cells in mice (reduced from ~90% to ~30%).
“Tissue cytometry revealed 90% transduction efficiency with p21+ cells reduced from ~90% to ~30%.”
Animalsfollowing focal cartilage injurycartilage
p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair
FASEB journal : official publication of the Federation of American Societies for Experimental Biology21 Apr 2026
Cartilage repair
upin mice1
1 study
Cartilage repair
upin mice1
P21 shRNA improves cartilage repair in mice.
“In vivo, p21 shRNA treatment significantly improved cartilage repair in both strains.”
Animalsfull-thickness cartilage defectscartilage
p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair
FASEB journal : official publication of the Federation of American Societies for Experimental Biology21 Apr 2026