P16-positive cell clearance
P16-positive cell clearance has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest paper, Aug 27, 2026: “Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging”.
1 paper studies it5 findingsUpdated
See all 1 papers on P16-positive cell clearance
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
1 of its findings points the other way.
- 1 lab in 1 country
- 1 finding against
- Funders: Glenn Foundation for Medical Research and 7 more
- Animals1
What did studies of P16-positive cell clearance find?
3Studies of P16-positive cell clearance measured 3 outcomes: lifespan, cognitive function and frailty.
Lifespan
upin mice2no changein mice1
2 studies
Lifespan
upin mice2no changein mice1
P16-positive cell clearance showed no clear effect on lifespan in mice (early clearance at 1 month after irradiation).
“Early clearance had no effect on lifespan or functional outcomes.”
Animalsearly clearance at 1 month after irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging
Aging cell
P16-positive cell clearance extends lifespan in mice (delayed clearance at 4 months after irradiation; benefit most evident in females).
“increased median survival, with the survival benefit being most evident in female mice”
Animalsdelayed clearance at 4 months after irradiation; benefit most evident in females
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging
Aging cell
P16-positive cell clearance extends lifespan in transgenic mouse models.
“removing cells expressing the senescence marker p16Ink4a (p16) can increase median lifespan”
Reviewin transgenic mouse models
Engineering Antibodies Targeting p16 MHC-Peptide Complexes
ACS chemical biology
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
P16-positive cell clearance improves cognitive function in mice (delayed clearance at 4 months after irradiation).
“improved neuromuscular and cognitive function”
Animalsdelayed clearance at 4 months after irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging
Aging cell
Frailty
downin mice1
1 study
Frailty
downin mice1
P16-positive cell clearance decreases frailty in mice (delayed clearance at 4 months after irradiation).
“delayed clearance markedly reduced frailty”
Animalsdelayed clearance at 4 months after irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging
Aging cell