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P16+ cell ablation

Exposure

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: KWF Kankerbestrijding
  • Animals1

Outcomes

4

Inflammation

downin mice1

1 study

  1. P16+ cell ablation decreases inflammation in mice.

    “p16+ cell removal shifts female liver expression toward youthful, health-associated profiles, marked by improved mitochondrial activity and reduced inflammatory signaling”

    Animalsliverfemales

    Integrative Omics Reveal Female-Specific Benefits of p16⁺ Cell Clearance in Aging Mice

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Oct 2025

More on Inflammation

Skin regeneration

upin mice1

1 study

  1. P16+ cell ablation improves skin regeneration in mice.

    “selective ablation of these cells enhances grip strength, promotes skin regeneration, and reduces liver damage exclusively in females.”

    Animalsskinfemales

    Integrative Omics Reveal Female-Specific Benefits of p16⁺ Cell Clearance in Aging Mice

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Oct 2025

Grip strength

upin mice1

1 study

  1. P16+ cell ablation improves grip strength in mice.

    “selective ablation of these cells enhances grip strength, promotes skin regeneration, and reduces liver damage exclusively in females.”

    Animalsfemales

    Integrative Omics Reveal Female-Specific Benefits of p16⁺ Cell Clearance in Aging Mice

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Oct 2025

Liver damage

downin mice1

1 study

  1. P16+ cell ablation decreases liver damage in mice.

    “In the p16-3MR model, selective ablation of these cells enhances grip strength, promotes skin regeneration, and reduces liver damage exclusively in females.”

    Animalsliverfemales

    Integrative Omics Reveal Female-Specific Benefits of p16⁺ Cell Clearance in Aging Mice

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Oct 2025

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