Oxyresveratrol

1. Oxyresveratrol inhibits MAPK/ERK signalling in mouse cells.

   “oxyresveratrol suppressed the phosphorylation of the RANKL-induced mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK”

   Cellsin RANKL-treated RAW 264.7 cells

   Oxyresveratrol attenuates bone resorption by inhibiting the mitogen-activated protein kinase pathway in ovariectomized rats

   Nutrition & metabolism·19 Jan 2024

More on MAPK/ERK signalling

1. Oxyresveratrol inhibits osteoclast differentiation in mouse cells.

   “The polyphenol oxyresveratrol inhibited receptor activator of nuclear factor kappa-Β ligand (RANKL)-induced osteoclast differentiation of RAW 264.7 cells.”

   Cellsin RAW 264.7 cells

   Oxyresveratrol attenuates bone resorption by inhibiting the mitogen-activated protein kinase pathway in ovariectomized rats

   Nutrition & metabolism·19 Jan 2024

1. Oxyresveratrol decreases lipofuscin in worms (-30.43% to -64.42%).

   “The fluorescence intensity of C. elegans pigments decreased by 30.43%, 47.35% and 64.42% after the treatment with a low, middle, and high OXY dose, respectively”

   Model organisms

   Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

   Food & function·10 Jul 2020

More on Lipofuscin

1. Oxyresveratrol extends lifespan in worms (+6.82% mean lifespan).

   “The mean lifespan of nematodes in the 50 μM OXY-treated group was significantly longer than that in the blank group by 6.82%.”

   Model organisms50 μM

   Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

   Food & function·10 Jul 2020

1. Oxyresveratrol induces apoptosis in mouse cells.

   “decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH) and increased catalase (CAT), leading to apoptosis”

   Cellsmurine melanoma B16 cellsmelanoma

   Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

   Food & function·10 Jul 2020

More on Apoptosis

1. Oxyresveratrol decreases melanin in mouse cells.

   “OXY decreased melanin production by inhibiting the tyrosinase activity in murine melanoma B16 cells”

   Cellsmurine melanoma B16 cellsmelanoma

   Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

   Food & function·10 Jul 2020

More on Melanin

1. Oxyresveratrol inhibits tyrosinase in A. bisporus cells (IC50 of 0.03 mM).

   “OXY significantly inhibited tyrosinase with a half maximal inhibitory concentration (IC50) of 0.03 mM”

   Cellsin vitro

   Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

   Food & function·10 Jul 2020

More on tyrosinase