Ovarian tissue transplantation

1. Ovarian tissue transplantation improves endocrine function in humans.

   “The OTT restored endocrine function, normalizing gonadotropin levels and resuming the menstrual cycle within three months”

   Human trialprior Hodgkin lymphomaovarian tissuethree monthsfemalesn = 1

   Ovarian Tissue Transplantation Using Autologous Platelet-Rich Plasma: Step-By-Step Surgical Technique

   Journal of minimally invasive gynecology·18 Jun 2026

2. Ovarian tissue transplantation improves endocrine function in humans.

   “recovery of endocrine function was observed in all but one woman who underwent orthotopic transplantation (13 of 14 cases), in one out of two women who underwent both orthotopic and heterotopic transplantation (1 of 2 cases) and in all women who underwent heterotopic transplantation (4 of 4 cases).”

   Humanspremature ovarian insufficiency and at least 6 months follow-uporthotopic, heterotopic, or bothovarian tissuefemalesn = 20

   Ovarian tissue transplantation: 10 years of experience at the Bologna University

   Frontiers in endocrinology·7 Mar 2024

1. Ovarian tissue transplantation improves healthspan.

   “ovarian transplantation may represent the most physiologically complete intervention for female post-menopausal aging currently within reach”

   Reviewfemales

   OVARIAN TRANSPLANTATION: FROM FERTILITY PRESERVATION TO GEROSCIENCE

   Zenodo (CERN European Organization for Nuclear Research)·4 May 2026Preprint

1. Ovarian tissue transplantation decreases sarcopenia.

   “reverses multiple hallmarks of systemic aging, including immune senescence, cardiovascular dysfunction, cognitive decline, renal impairment, and sarcopenia”

   Reviewfemales

   OVARIAN TRANSPLANTATION: FROM FERTILITY PRESERVATION TO GEROSCIENCE

   Zenodo (CERN European Organization for Nuclear Research)·4 May 2026Preprint

More on Sarcopenia

1. Ovarian tissue transplantation extends lifespan (approximately 40%).

   “transplantation of young ovaries into aged females extends maximum lifespan by approximately 40%”

   Reviewfemales

   OVARIAN TRANSPLANTATION: FROM FERTILITY PRESERVATION TO GEROSCIENCE

   Zenodo (CERN European Organization for Nuclear Research)·4 May 2026Preprint

1. Ovarian tissue transplantation increases pregnancy in humans (10 pregnancies in 25 women).

   “In total, ten pregnancies were obtained in 25 women, resulting in four live births, two ongoing pregnancies and four spontaneous abortions.”

   Humanswomen seeking fertility enhancement or after POIorthotopic and/or heterotopicovarian tissuefemalesn = 25

   Ovarian tissue transplantation: 10 years of experience at the Bologna University

   Frontiers in endocrinology·7 Mar 2024

1. Ovarian tissue transplantation has no effect on DNA methylation in mice.

   “Methylation status of the H19 and Lit1 Imprinting Control Regions in kidney, muscle and tongue of offsprings from grafted mice does not show significant alteration”

   Animalskidney, muscle and tongue of offsprings

   Immature cryopreserved ovary restores puberty and fertility in mice without alteration of epigenetic marks

   PloS one·16 Apr 2008

More on DNA methylation

1. Ovarian tissue transplantation decreases follicle density in mice.

   “a significant reduction in follicle density was observed with or without cryopreservation”

   Animalswith or without cryopreservation

   Immature cryopreserved ovary restores puberty and fertility in mice without alteration of epigenetic marks

   PloS one·16 Apr 2008

More on Follicle density

1. Ovarian tissue transplantation improves fertility in mice.

   “Although fertility was restored, the graft is of limited life span.”

   Animalsusing fresh or cryopreserved immature grafts

   Immature cryopreserved ovary restores puberty and fertility in mice without alteration of epigenetic marks

   PloS one·16 Apr 2008

1. Ovarian tissue transplantation improves puberty in mice.

   “Puberty as well as cyclic hormonal activity was restored.”

   Animalsusing fresh or cryopreserved immature grafts

   Immature cryopreserved ovary restores puberty and fertility in mice without alteration of epigenetic marks

   PloS one·16 Apr 2008