Osteocalcin
Intervention1 paper1 finding
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Animals1
Outcomes
1Locomotor function
upin mice1
1 study
Locomotor function
upin mice1
Osteocalcin improves locomotor function in mice.
“OCN restoration in aged mice reverses age-related locomotor decline through a mechanism that requires MN autophagy and mitophagy.”
Animalsage-related locomotor decline
A bone hormone reverses age-related movement decline in mice · bioRxiv · 8 Oct 2026 · Preprint
Latest
1A bone hormone reverses age-related movement decline in mice
In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor…In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor neurons.