Orthodontic force

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
1 finding against

Funders: Japan Science and Technology Agency and 1 more

Animals1

Outcomes

Angiogenesis

downin rats1upin rats1

1 study

Orthodontic force decreases angiogenesis in rats.
“In contrast, the 180 g group reduced cellularity and angiogenesis, consistent with excessive force.”
Animalsorthodontic tooth movementperiodontal tissue180 gmales
Force-Dependent Presence of Senescent Cells Expressing Vascular Endothelial Growth Factor During Orthodontic Tooth Movement
Biology19 Jan 2026
Orthodontic force increases angiogenesis in rats.
“The 60 g group showed increased cellularity, vascular density, and VEGF expression, suggesting an optimal mechanical force.”
Animalsorthodontic tooth movementperiodontal tissue60 gmales
Force-Dependent Presence of Senescent Cells Expressing Vascular Endothelial Growth Factor During Orthodontic Tooth Movement
Biology19 Jan 2026