Oolonghomobisflavan a

Oolonghomobisflavan a inhibits tau fibril seeding in human cells.

“also inhibited seeding in assays using ex vivo brain-derived paired helical filament tau protein fibrils from Alzheimer's disease brain donors”

Cellsusing ex vivo brain-derived paired helical filament tau protein fibrils from Alzheimer's disease brain donors

Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy

Life science alliance·17 Nov 2025

Oolonghomobisflavan a decreases tau protein aggregation in worms.

“OFA treatment reduced the burden of tau protein aggregation and promoted tau disaggregation in hTau-expressing C. elegans”

Model organismsin hTau-expressing C. elegans

Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy

Life science alliance·17 Nov 2025

Oolonghomobisflavan a improves healthspan in worms.

“reverse the shortened lifespan in a Caenorhabditis elegans model expressing pathogenic human tau ("hTau-expressing"), but increase healthspan”

Model organismsin hTau-expressing C. elegans

Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy

Life science alliance·17 Nov 2025