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NT-0249

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Funder: University of Washington
  • Animals1

Outcomes

2

GFAP

downin mice1

1 study

  1. NT-0249 decreases GFAP in mice.

    “DIO-driven hypothalamic glial fibrillary acidic protein expression is blocked by dosing with NT-0249/NT-0796”

    Animalsdiet-induced obesityhypothalamus

    Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796

    The Journal of pharmacology and experimental therapeutics10 Feb 2024

More on GFAP

Obesity

downin mice1

1 study

  1. NT-0249 decreases obesity in mice.

    “NT-0249 and NT-0796, reverse obesity in the DIO mouse model”

    Animalsdiet-induced obesity

    Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796

    The Journal of pharmacology and experimental therapeutics10 Feb 2024

More on Obesity

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