Nnmt inhibitor
2 papers study it3 findings
Across all fields, 2 papers: none in people yet, 1 in animals, 1 review
- 1 lab in 1 country
- Funders: National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and 3 more
- Animals1
Outcomes
3NAD+
upin mice1
1 study
NAD+
upin mice1
Nnmt inhibitor increases NAD+ in mice.
“the NNMTi treatment increased the levels of nicotinamide adenine dinucleotide (NAD+) content”
Animalsin D-galactose-treated and naturally aging miceskeletal muscle
Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia
Aging cell
Muscle mass
upin mice1
1 study
Muscle mass
upin mice1
Nnmt inhibitor increases muscle mass in mice.
“alleviated age-related decline in the mass index of the quadriceps femoris muscles and whole-body lean mass index”
Animalsin aging micequadriceps femoris muscle
Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia
Aging cell
Grip strength
upin mice1
1 study
Grip strength
upin mice1
Nnmt inhibitor improves grip strength in mice.
“inhibition of NNMT improved the grip strength in aging mice”
Animalsin aging mice
Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia
Aging cell