Never-married status

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 1 more

Humans2

Associations

Cognitive impairment

upin humans1

1 study

Never-married status is associated with cognitive impairment in humans (AOR 23.809, 95% CI 1.445–392.218).
“Never-married individuals had significantly higher odds of cognitive impairment compared to those who were ever married”
HumansNever-married versus ever-married individuals in rural Ernakulam, Kerala, India; multivariable-adjusted associationn = 175
Prevalence of Cognitive Impairment and Its Associated Factors in a Rural Area of Ernakulam District, Kerala, India
Cureus17 Sep 2025