Neighborhood physical disadvantage

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans2

Associations

Group Four cognitive trajectory

upin humans1

1 study

Neighborhood physical disadvantage is associated with group Four cognitive trajectory in humans (RRR=1.23, p < 0.01).
“Four (RRR=1.23, p < 0.01)”
Humansrelative to Group One
Neighborhood Physical Disadvantage, Education, and Cognitive Decline Trajectories in U.S. Older Adults
GSA 2025 abstract31 Dec 2025

Group Three cognitive trajectory

upin humans1

1 study

Neighborhood physical disadvantage is associated with group Three cognitive trajectory in humans (RRR=1.33, p<.001).
“Three (RRR=1.33, p<.001)”
Humansrelative to Group One
Neighborhood Physical Disadvantage, Education, and Cognitive Decline Trajectories in U.S. Older Adults
GSA 2025 abstract31 Dec 2025

Group Two cognitive trajectory

upin humans1

1 study

Neighborhood physical disadvantage is associated with group Two cognitive trajectory in humans (RRR=1.28, p < 0.001).
“Two (RRR=1.28, p < 0.001)”
Humansrelative to Group One
Neighborhood Physical Disadvantage, Education, and Cognitive Decline Trajectories in U.S. Older Adults
GSA 2025 abstract31 Dec 2025

Group One cognitive trajectory

upin humans1

1 study

Neighborhood physical disadvantage is associated with group One cognitive trajectory in humans (RRR=1.17, P < 0.01).
“neighborhood physical disadvantage was associated with higher odds of belonging to Group One (RRR=1.17, P < 0.01)”
Humansrelative to Group One
Neighborhood Physical Disadvantage, Education, and Cognitive Decline Trajectories in U.S. Older Adults
GSA 2025 abstract31 Dec 2025