Neighborhood environment

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 2 more

Humans4

Outcomes

Mental health

downin humans1

1 study

Neighborhood environment impairs mental health in humans.
“Compared to their counterparts living in affluent neighborhoods, older adults residing in disadvantaged neighborhoods and those in mid-SES with high hazards neighborhoods experienced greater chronic conditions, worse mental health, and more functional limitations.”
Humansliving in disadvantaged or mid-SES with high hazards neighborhoods compared to affluent neighborhoodsn = 8,474
CLUSTERING OF MULTIDIMENSIONAL NEIGHBORHOOD CHARACTERISTICS IN SHAPING HEALTHY AGING
GSA 2024 abstract31 Dec 2024

Associations

Dementia

upin humans1HR 1.26

1 study

Neighborhood environment is associated with dementia in humans (HR 1.26, 95% CI 1.08–1.47).
“Compared with low-risk neighborhoods, moderate-risk (HR = 1.26, 95% CI: 1.08-1.47), and high-risk neighborhoods (HR = 1.41, 95% CI: 1.13-1.77) independently increased dementia risk.”
HumansModerate-risk versus low-risk neighborhoods; adjusted analysisMedian follow-up of 9 yearsn = 8,107
Association of intrinsic capacity and neighborhood environment with dementia risk: an interaction and mediation analysis
Innovation in aging11 Dec 2025