Intrinsic Capacity Impairment Score

1. Life's essential 8 has no effect on Intrinsic Capacity Impairment Score in humans (-0.02 points per year (95% CI: -0.16; 0.12)).

   Humansper 10-point higher LE85.2-year follow-upn = 2,487

   Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories · GeroScience · 23 Sep 2026

2. Life's essential 8 decreases Intrinsic Capacity Impairment Score in humans (-3.44 points (95% CI: -3.98; -2.91)).

   Humansper 10-point higher LE8femalesn = 2,487

   Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories · GeroScience · 23 Sep 2026

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