Nampt

1. Nampt increases energy expenditure in mice.

   “elevation of plasma eNAMPT by NAMPT administration increases hypothalamic NAD+ levels and stimulates LMA and EE”

   Animals

   Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

   Nature communications·Apr 8, 2023

1. Nampt increases locomotor activity in mice.

   “elevation of plasma eNAMPT by NAMPT administration increases hypothalamic NAD+ levels and stimulates LMA and EE”

   Animals

   Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

   Nature communications·Apr 8, 2023

1. Nampt increases hypothalamic NAD+ in mice.

   “elevation of plasma eNAMPT by NAMPT administration increases hypothalamic NAD+ levels and stimulates LMA and EE”

   Animals

   Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

   Nature communications·Apr 8, 2023

More on Hypothalamic NAD+

1. Nampt prevents muscle disuse atrophy in O. cuniculus.

   “NAMPT-elevated NAD+ biosynthesis was also efficient in preventing EDL disuse atrophy by reversing mitochondrial dysfunction.”

   Animalsextensor digitorum longus disuse atrophyextensor digitorum longus

   Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

   Journal of cachexia, sarcopenia and muscle·Mar 2, 2023

More on Muscle disuse atrophy

1. Nampt increases NAD+ metabolism in O. cuniculus (279.9 ± 48.7 to 392.2 ± 43.2 pmol/mg).

   “and NAD+ biosynthesis (279.9 ± 48.7 to 392.2 ± 43.2 pmol/mg, P = 0.0023).”

   Animalsin acute disuse of supraspinatus musclesupraspinatus muscle

   Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

   Journal of cachexia, sarcopenia and muscle·Mar 2, 2023

More on NAD+ metabolism

1. Nampt increases citrate synthase activity in O. cuniculus (40.8 ± 6.3 to 50.5 ± 5.6 nmol/min/mg).

   “Disuse-induced impairment of mitochondrial function were significantly improved by NAMPT, including citrate synthase activity (40.8 ± 6.3 to 50.5 ± 5.6 nmol/min/mg, P = 0.0043)”

   Animalsin acute disuse of supraspinatus musclesupraspinatus muscle

   Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

   Journal of cachexia, sarcopenia and muscle·Mar 2, 2023

More on Citrate synthase activity

1. Nampt increases muscle mass in O. cuniculus (6.17 ± 0.54 g vs 5.10 ± 0.79 g).

   “reversed by NAMPT (muscle mass 6.17 ± 0.54 g, P = 0.0033; fibre CSA, 3219.8 ± 289.4 μm2 , P = 0.0018)”

   Animalsin acute disuse of supraspinatus musclesupraspinatus muscle

   Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

   Journal of cachexia, sarcopenia and muscle·Mar 2, 2023