Naltrexone
Across all fields, 6 papers: 3 trials in people, 2 in animals
- 2 independent labs in 3 countries
- 1 finding against
- Funders: Amsterdam University Medical Centers and others
- Human trial3
- Model organisms2
Outcomes
6Lifespan
upin worms2no changein worms1
2 studies
Lifespan
upin worms2no changein worms1
Naltrexone has no effect on lifespan in worms.
“low dose, but not high dose, of naltrexone extended the healthspan and lifespan.”
Model organismshigh dose
Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation
iScience
Naltrexone extends lifespan in worms.
“low dose, but not high dose, of naltrexone extended the healthspan and lifespan.”
Model organismslow dose
Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation
iScience
Naltrexone extends lifespan in worms.
“We found that a low, but not high dose of naltrexone extended both healthspan and lifespan in C. elegans worms.”
Model organismslow dose
Research SquarePreprint
Healthspan
upin worms2
2 studies
Healthspan
upin worms2
Naltrexone improves healthspan in worms.
“low dose, but not high dose, of naltrexone extended the healthspan and lifespan.”
Model organismslow dose
Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation
iScience
Naltrexone improves healthspan in worms.
“We found that a low, but not high dose of naltrexone extended both healthspan and lifespan in C. elegans worms.”
Model organismslow dose
Research SquarePreprint
Oxidative stress and ROS signaling
upin worms1
1 study
Oxidative stress and ROS signaling
upin worms1
Naltrexone activates oxidative stress and ROS signaling in worms.
“LDN treatment not only increased the expression of innate immune genes but also activated the oxidative stress response in worms”
Model organismslow dose
Research SquarePreprint
Innate immune gene expression
upin worms1
1 study
Innate immune gene expression
upin worms1
Naltrexone increases innate immune gene expression in worms.
“LDN treatment not only increased the expression of innate immune genes but also activated the oxidative stress response in worms”
Model organismslow dose
Research SquarePreprint
Smoking cessation
no changein humans1
1 study
Smoking cessation
no changein humans1
Naltrexone has no effect on smoking cessation in humans (22% vs 27%, p = 0.43).
“Seven-day point-prevalence smoking abstinence rates at 26 weeks post-quit was not significantly different between the 2 groups (naltrexone: 22% vs placebo: 27%, p = 0.43).”
Human trial25 mg27 weeksn = 172
Drug and alcohol dependence
Body weight
no changein humans1
1 study
Body weight
no changein humans1
Naltrexone has no effect on body weight in humans (6.8 lbs ± 8.94 vs 9.7 lbs ± 9.19, p = 0.45).
“The difference in weight at 26 weeks post-quit between the naltrexone and placebo groups (naltrexone: 6.8 lbs ± 8.94 vs placebo: 9.7 lbs ± 9.19, p = 0.45) was not statistically different.”
Human trial25 mg27 weeksn = 172
Drug and alcohol dependence