Naldemedine
Intervention1 paper1 findingPubChem 54732242
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
- Cells1
Outcomes
1disulfidptosis
downin cells1
1 study
disulfidptosis
downin cells1
Naldemedine inhibits disulfidptosis in cells.
CellsSLC7A11-dependent disulfidptosis in senile osteoporosis
Lamin B1 deficiency impairs bone formation in stem cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 8 Oct 2026
Latest
1Lamin B1 deficiency impairs bone formation in stem cells
In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone…In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.