NADH/NAD+ ratio normalization

Exposure

1 paper1 finding

  • 1 lab
  • Cells1

Outcomes

1

Cell proliferation

no changein human cells1

1 study
  1. NADH/NAD+ ratio normalization has no effect on cell proliferation in human cells.

    “normalizing the NADH/NAD+ ratio alone while NADPH depletion persists fails to rescue proliferation in EcSTH-expressing primary human cells”

    CellsEcSTH expression with persistent NADPH depletionprimary human cell

    Linked metabolic disruptions halt division in human cells

    Nature metabolism14 Oct 2026

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Nature Metabolism

Linked metabolic disruptions halt division in human cells

An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.

Experiments in human cellsInterventions