N-acetylneuraminic acid

2 papers5 findings

MeSH D019158

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs

Humans1
Animals1

Outcomes

Inflammation

downin mice1

1 study

N-acetylneuraminic acid decreases inflammation in mice.
“alleviated systemic and local inflammation by suppressing macrophage infiltration and polarization toward the pro-inflammatory phenotype”
Animalsin natural aging and DSS-induced colitis modelsoral
Dietary N-acetylneuraminic acid maintains intestinal homeostasis and protects against aging- and inflammation-associated colonic dysfunction
International immunopharmacology25 Mar 2026

Associations

Parabacteroides abundance

upin humans1

1 study

N-acetylneuraminic acid is associated with Parabacteroides abundance in humans.
“Fecal sialic acid (Neu5Ac) levels were positively correlated with the abundance of Parabacteroides.”
Humansin older adults
Sialic acid-responsive Parabacteroides is linked to gut barrier integrity in older adults
Gut microbes10 Feb 2026