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MZ-5-156

MZ-5-156 has been studied in 1 paper since 2010: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 6, 2010: “Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice”.

Intervention

1 paper studies it6 findingsUpdated

MeSH

More peptides

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 3 more
  • Animals1

What did studies of MZ-5-156 find?

5

Studies of MZ-5-156 measured 5 outcomes; the most studied are lifespan (1 study), cognitive function (1) and pole balance (1).

Lifespan

upin mice1

1 study

  1. MZ-5-156 extends lifespan in mice (+8 wk mean life expectancy).

    “Mean life expectancy increased by 8 wk with no increase in maximal life span”

    Animals10 μg/mouse

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

Cognitive function

upin mice1

1 study

  1. MZ-5-156 improves cognitive function in mice.

    “MZ-5-156 improved cognition after 2 mo and 4 mo, but not after 7 mo of treatment”

    Animals10 μg/mouse2 mo and 4 mo

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

Pole balance

upin mice1

1 study

  1. MZ-5-156 improves pole balance in mice.

    “improved pole balance, but no change in muscle strength”

    Animals10 μg/mouse4 mo

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

Oxidative stress and ROS signaling

downin mice1

1 study

  1. MZ-5-156 decreases oxidative stress and ROS signaling in mice.

    “improvement in some measures of oxidative stress in brain”

    Animalsbrain10 μg/mouse4 mo

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

More on Oxidative stress and ROS signaling

Telomerase activity

upin mice1

1 study

  1. MZ-5-156 increases telomerase activity in mice.

    “Mice treated for 4 mo with MZ-5-156 showed increased telomerase activity”

    Animals10 μg/mouse4 mo

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

More on Telomerase activity

What is MZ-5-156 linked with?

1

Studies link MZ-5-156 with 1 measure, most often tumor (1 study).

Tumor

downin mice1

1 study

  1. MZ-5-156 lowers the risk of tumor in mice (from 10 to 1.7%).

    “tumor incidence decreased from 10 to 1.7%”

    Animals10 μg/mouse

    Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

    Proceedings of the National Academy of Sciences of the United States of America

More on Tumor

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