Mycophenolate

1 paper studies it14 more mention it2 findings

1 lab in 1 country
1 finding against
2 trials, none about aging

Funders: American Thoracic Society and others

Humans1

Outcomes

1

Mortality

no changein humans1

1 study

Mycophenolate has no effect on mortality in humans.
“Immunosuppressant exposure was not associated with differential survival in patients with LTL ≥10th percentile.”
Humansin patients with LTL >=10th percentile2-year
Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease
The European respiratory journalAug 17, 2023

Associations

1

Mortality

upin humans1HR 4.97

1 study

Mycophenolate raises the risk of mortality in humans (HR 4.97, 95% CI 2.26-10.92, p<0.001).
“fHP and uILD patients with LTL <10th percentile experienced reduced survival when exposed to either mycophenolate or azathioprine in the discovery cohort (mortality hazard ratio (HR) 4.97, 95% CI 2.26-10.92; p<0.001)”
Humansin fHP and uILD patients with LTL <10th percentile (discovery cohort)2-yearn = 613
Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease
The European respiratory journalAug 17, 2023

Trial sponsors

Novartis Pharmaceuticals Corporation
Company1 trialPhase 4126 people
Sanofi
Company1 trialPhase 2/3526 people

Latest

3 papers in 12 months

CureusAug 12

Clinical Predictors and Outcomes of Post-transplantation Diabetes Mellitus in an Indian Kidney Transplant Cohort: The Predictive Value of Early Postoperative Hyperglycaemia

Cohort study of 40 peopleKidney

Science AdvancesJul 8

VCAM-1-targeting peptide assemblies protect vascular endothelium and prolong cardiac xenograft survival

Experiments in pigsInterventions

bioRxivNov 24

Coordinated circulating and tissue-based T cell responses precede xenograft rejection

Preprint: case reportGraft rejection

Frontiers in AgingOct 30

Sirolimus use in allogeneic hematopoietic cell transplant recipients: assessing its senotherapeutic role in a high risk population

Cohort study in peopleRapamycin

Cell Death DiscoveryJun 5

ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration

Study in peopleCellular senescence

Hematology American Society of Hematology Education ProgramDec 7

Beyond FAScinating: advances in diagnosis and management of autoimmune lymphoproliferative syndrome and activated PI3 kinase δ syndrome

ReviewInterventions

GeroScienceDec 2

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Experiments in miceFisetin

The European Respiratory JournalAug 17

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

Cohort study of 613 peopleTelomere length

TransplantationMay 11

Enhanced Humoral Immune Response After COVID-19 Vaccination in Elderly Kidney Transplant Recipients on Everolimus Versus Mycophenolate Mofetil-containing Immunosuppressive Regimens

Randomized trial in 32 peopleKidney

AgingMar 25

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Study in peopleInterventions