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Multistrain probiotic

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Chosun University and 1 more
  • Human trial1

Outcomes

2

Cortical thickness

downin humans1

1 study

  1. Multistrain probiotic decreases cortical thickness in humans.

    “Cortical thickness decreased modestly in these regions in the probiotic group.”

    Human trialbrain52 weeksn = 68

    Probiotics linked to brain surface area changes in older adults

    Research Square14 Oct 2026Preprint

More on Cortical thickness

Cortical surface area

upin humans1

1 study

  1. Multistrain probiotic increases cortical surface area in humans (+ 21.53 vs. −54.39 mm2, p = 3.12 × 10−4).

    “Compared with placebo, the probiotic group showed increased surface area in the left lingual gyrus (+ 21.53 vs. −54.39 mm2, p = 3.12 × 10−4)”

    Human trialleft lingual gyrus52 weeksn = 68

    Probiotics linked to brain surface area changes in older adults

    Research Square14 Oct 2026Preprint

More on Cortical surface area

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Research Square

Probiotics linked to brain surface area changes in older adults

Surface area in one brain region increased by 21.53 square millimetres with probiotics, against a fall of 54.39 square millimetres with placebo over 52 weeks.Surface area in one brain region increased by 21.53 square millimetres with probiotics, against a fall of 54.39 square millimetres with placebo over 52 weeks.

Preprint: randomised trial in 68 older adults with early cognitive impairment, 52 weeks, against placeboProbiotics

Limit: Excluding participants without repeat, analyzable MRI could bias the comparison

Paper

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