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Multidomain outdoor exercise

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Ministry of Culture and Sport and 1 more
  • Human trial1

Outcomes

3

Six Minute Walk Test

upin humans1

1 study

  1. Multidomain outdoor exercise improves six Minute Walk Test in humans (+64.7 m (95% CI 45.9 to 83.5)).

    “Six-Minute Walk Test improvement of 64.7 m (95% CI: 45.9 to 83.5, p < 0.001, ηp2 = 0.463).”

    Human trialCompared with controlOutdoor sessions integrating resistance, aerobic training, balance, and cognitive exercisesTwice-weekly, 60 min sessions18 weeksn = 46

    Impact of a Multidomain Outdoor Exercise Intervention on Cardiovascular Health and Functional Capacity for Healthy Aging: A Randomized Controlled Trial (ACTIVA-Senior Study)

    Healthcare (Basel, Switzerland)12 Aug 2025

Diastolic blood pressure

downin humans1

1 study

  1. Multidomain outdoor exercise decreases diastolic blood pressure in humans (-9.2 mmHg (95% CI -12.1 to -6.3)).

    “diastolic blood pressure reduction of 9.2 mmHg (95% CI: -12.1 to -6.3, p < 0.001, ηp2 = 0.248)”

    Human trialCompared with controlOutdoor sessions integrating resistance, aerobic training, balance, and cognitive exercisesTwice-weekly, 60 min sessions18 weeksn = 46

    Impact of a Multidomain Outdoor Exercise Intervention on Cardiovascular Health and Functional Capacity for Healthy Aging: A Randomized Controlled Trial (ACTIVA-Senior Study)

    Healthcare (Basel, Switzerland)12 Aug 2025

More on Diastolic blood pressure

Systolic blood pressure

downin humans1

1 study

  1. Multidomain outdoor exercise decreases systolic blood pressure in humans (-17.4 mmHg (95% CI -21.9 to -12.9)).

    “a systolic blood pressure reduction of 17.4 mmHg (95% CI: -21.9 to -12.9, p < 0.001, ηp2 = 0.376)”

    Human trialCompared with controlOutdoor sessions integrating resistance, aerobic training, balance, and cognitive exercisesTwice-weekly, 60 min sessions18 weeksn = 46

    Impact of a Multidomain Outdoor Exercise Intervention on Cardiovascular Health and Functional Capacity for Healthy Aging: A Randomized Controlled Trial (ACTIVA-Senior Study)

    Healthcare (Basel, Switzerland)12 Aug 2025

More on Systolic blood pressure

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