Mp compounds
1 paper5 findings
- 1 lab in 1 country
- Funders: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas and 4 more
- Model organisms1
Outcomes
5Locomotor activity
upin flies1
1 study
Locomotor activity
upin flies1
Mp compounds improve locomotor activity in flies.
“treatment with MP compounds significantly extended the lifespan and improved the locomotor activity of a Drosophila model of the DM1 disease”
Model organismsmyotonic dystrophy type 1 model
Cells22 Nov 2024
Lifespan
upin flies1
1 study
Lifespan
upin flies1
Mp compounds extend lifespan in flies.
“treatment with MP compounds significantly extended the lifespan and improved the locomotor activity of a Drosophila model of the DM1 disease”
Model organismsmyotonic dystrophy type 1 model
Cells22 Nov 2024
Alternative splicing defects
downin human cells1
1 study
Alternative splicing defects
downin human cells1
Mp compounds decrease alternative splicing defects in human cells.
“This analysis also revealed the rescue of alternative splicing events in DM1 fibroblasts treated with MP compounds.”
Cellsmyotonic dystrophy type 1primary fibroblast
Cells22 Nov 2024
Mitochondrial activity
upin human cells1
1 study
Mitochondrial activity
upin human cells1
Mp compounds improve mitochondrial activity in human cells.
“reversed oxidative stress and impaired cell viability and proliferation, mitochondrial activity, and metabolic defects in DM1-derived primary fibroblasts.”
Cellsderived from myotonic dystrophy type 1 patientsprimary fibroblast
Cells22 Nov 2024
Oxidative stress and ROS signalling
downin human cells1
1 study
Oxidative stress and ROS signalling
downin human cells1
Mp compounds decrease oxidative stress and ROS signalling in human cells.
“The treatment with different MP compounds reversed oxidative stress”
Cellsderived from myotonic dystrophy type 1 patientsprimary fibroblast
Cells22 Nov 2024