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Mood instability symptoms

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Natural Science Foundation of Ningxia Province
  • Humans1

Associations

3

Mortality

upin humans1HR 1.07

1 study

  1. Mood instability symptoms raise the risk of mortality in humans (HR = 1.07, 95% CI: 1.01-1.14).

    “all-cause mortality (HR = 1.07, 95% CI: 1.01-1.14)”

    Humanscompared to individuals with a pattern of stable

    The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality

    BMC medicine30 Oct 2025

Parkinson's disease

upin humans1HR 1.47

1 study

  1. Mood instability symptoms raise the risk of Parkinson's disease in humans (HR = 1.47, 95% CI: 1.21-1.77).

    “Parkinson's disease (HR = 1.47, 95% CI: 1.21-1.77)”

    Humanscompared to individuals with a pattern of stable

    The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality

    BMC medicine30 Oct 2025

More on Parkinson's disease

Dementia

upin humans1HR 1.17

1 study

  1. Mood instability symptoms raise the risk of dementia in humans (HR = 1.17, 95% CI: 1.02-1.35).

    “severe mood instability symptoms at baseline was significantly associated with an increased risk of all-cause dementia (hazard ratio [HR] = 1.17, 95% CI: 1.02-1.35)”

    Humanscompared to individuals with a pattern of stable

    The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality

    BMC medicine30 Oct 2025

More on Dementia

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