Monoamine oxidase inhibitors

1. Monoamine oxidase inhibitors raise the risk of dementia in humans (HR=2.15, 95% CI 1.39-3.34).

   “Compared to untreated patients, all patients treated with antidepressants, but not those treated with psychotherapy only, showed a significantly greater risk of dementia, especially MAOIs (HR=2.15,95% confidence interval [CI] 1.39−3.34)”

   Humansmajor depressive disordern = 56,423

   Treatments for Depression and the Risk of Dementia: A 23‐Year Cohort Study Using Akrivia Health Secondary Mental Healthcare Data

   AAIC 2025 abstract·23 Dec 2025

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