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Mirtazapine

Mirtazapine has been studied in 7 papers since 2023: 4 observational studies in people, 2 reviews; 4 in the past year. It is an approved medicine. The newest paper, Nov 3, 2026: “From prescription to prognosis: longitudinal associations between different antidepressant classes on medical comorbidity in those with bipolar disorder”.

InterventionApproved 1996

7 papers study it7 more mention it5 findingsUpdated

PubChemChEBIMeSH

1 new paper in 30 daysSee all 14 papers on mirtazapine

At a glance

The findings reach people, from one lab or study. 2 independent labs in 3 countries; 51 trials, none about aging, 24 with no results posted.

“and to mirtazapine (0.76 [0.65-0.88]) and trazodone (0.75 [0.63-0.90]).”
Antidepressants and Risk of Mortality in People with Depressive Disorder and Co-Occurring Type 2 Diabetes Mellitus: A 20-Year Population-Based Cohort StudyPsychotherapy and psychosomatics2026doi:10.1159/000550667

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

About aging: the drug’s trials about aging. The total counts its trials for every use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

  • 2 independent labs in 3 countries
  • 51 trials, none about aging, 24 with no results posted
  • Funder: The University of Hong Kong
  • Humans4

What did studies of mirtazapine find?

4

Studies of mirtazapine measured 4 outcomes, among them sleep, mood and semaglutide therapy continuation and dose advancement.

Sleep

upin humans1

1 study

  1. Mirtazapine is linked with better sleep in humans.

    “Additional benefits included enhanced mood, better sleep, and overall well-being.”

    Humansfemalesn = 1

    Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults

    Endocrine regulations

Mood

upin humans1

1 study

  1. Mirtazapine is linked with better mood in humans.

    “Additional benefits included enhanced mood, better sleep, and overall well-being.”

    Humansfemalesn = 1

    Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults

    Endocrine regulations

Semaglutide therapy continuation and dose advancement

upin humans1

1 study

  1. Mirtazapine is linked with better semaglutide therapy continuation and dose advancement in humans during semaglutide therapy with severe nausea, vomiting and diarrhea.

    “enabling continued semaglutide therapy and successful dose advancement”

    Humansduring semaglutide therapy with severe nausea, vomiting and diarrheafemalesn = 1

    Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults

    Endocrine regulations

Gastrointestinal side effects

downin humans1

1 study

  1. Mirtazapine is linked with lower gastrointestinal side effects in humans during semaglutide therapy (significant improvement in gastrointestinal tolerance (patient report)).

    “the patient reported significant improvement in gastrointestinal tolerance enabling continued semaglutide therapy”

    Humansduring semaglutide therapyfemalesn = 1

    Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults

    Endocrine regulations

More on Gastrointestinal side effects

What is mirtazapine linked with?

1

Studies link mirtazapine with mortality.

Mortality

downin humans1HR 0.76

1 study

  1. Mirtazapine is linked with a lower risk of mortality in depression patients with incident diabetes (HR 0.76, 95% CI 0.65-0.88).

    “and to mirtazapine (0.76 [0.65-0.88]) and trazodone (0.75 [0.63-0.90]).”

    Humansin depression patients with incident diabetes

    Antidepressants and Risk of Mortality in People with Depressive Disorder and Co-Occurring Type 2 Diabetes Mellitus: A 20-Year Population-Based Cohort Study

    Psychotherapy and psychosomatics

Has mirtazapine been tested in people?

0 of 51 about aging

Yes: 4 observational studies in people have been published, and 51 trials are registered.

Approved

Repurposing

40 of 49

In trials

  • Asperger syndrome

    Phase 3Results posted1 trial

  • Autistic disorder

    Phase 3Results posted1 trial

  • Hyperemesis gravidarum

    Phase 2Terminated1 trial

Stopped

  • NCT01465919TerminatedDepression

    Due to the recent change in standard of care for hepatitis C.

  • NCT04155008TerminatedHead and neck neoplasm

    The trial was closed after 4 months due to slow to accrual. Only 1 participant was enrolled.

  • NCT04763135TerminatedTumor

    difficulties in recruiting

  • NCT03785691TerminatedHyperemesis gravidarum

    Recruiting difficulties

Who is developing mirtazapine?

1 company: Teva Pharmaceuticals USA.

Companies

Trial sponsors

Latest

Dec 2025: 1Jan 2026: 1Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 14 papers in 12 months

See all 14 papers on mirtazapine

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