SGLT2 inhibitors + mineralocorticoid receptor antagonists

Intervention

1 paper3 findings

  • 1 lab in 1 country
  • Humans1

Outcomes

1

renin-angiotensin-aldosterone system

upin humans1

1 study
  1. SGLT2 inhibitors + mineralocorticoid receptor antagonists activate renin-angiotensin-aldosterone system in humans.

    “Groups A and B showed activation of the renin-angiotensin-aldosterone system”

    HumansHeart failure; initiation of combined therapy (Group A)30 days

    Combined SGLT-2 Inhibitor and Mineralocorticoid Receptor Antagonist Therapy: Effects on the Renin-Angiotensin-Aldosterone System in Heart Failure Treatment

    International journal of molecular sciences24 Sep 2026

Associations

2

Urinary albumin excretion

downin humans1

1 study
  1. SGLT2 inhibitors + mineralocorticoid receptor antagonists are associated with urinary albumin excretion in humans.

    “Group A exhibited increased 24 h urinary sodium and chloride excretion and lower urinary albumin excretion.”

    HumansHeart failure; initiation of combined therapy (Group A)30 days

    Combined SGLT-2 Inhibitor and Mineralocorticoid Receptor Antagonist Therapy: Effects on the Renin-Angiotensin-Aldosterone System in Heart Failure Treatment

    International journal of molecular sciences24 Sep 2026

More on Urinary albumin excretion

24-hour urinary sodium and chloride excretion

upin humans1

1 study
  1. SGLT2 inhibitors + mineralocorticoid receptor antagonists are associated with 24-hour urinary sodium and chloride excretion in humans.

    “Group A exhibited increased 24 h urinary sodium and chloride excretion and lower urinary albumin excretion.”

    HumansHeart failure; initiation of combined therapy (Group A)30 days

    Combined SGLT-2 Inhibitor and Mineralocorticoid Receptor Antagonist Therapy: Effects on the Renin-Angiotensin-Aldosterone System in Heart Failure Treatment

    International journal of molecular sciences24 Sep 2026

More on 24-hour urinary sodium and chloride excretion

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