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Middle cerebral artery occlusion

Intervention

15 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 8 independent labs in 4 countries
  • Funders: National Institutes of Health and others

What did studies of Middle cerebral artery occlusion find?

13

Studies of Middle cerebral artery occlusion measured 13 outcomes; the most studied are cellular senescence (3 studies), reactive astrogliosis (1) and cognitive dysfunction (1).

Cellular senescence

upin mice2upin rats1

3 studies

  1. Middle cerebral artery occlusion increases cellular senescence in mice.

    “Histological and flow cytometric analyses revealed a significant increase in hippocampal gliosis, white matter degradation, senescent cell accumulation, and dysregulated microglial function.”

    Animalsafter middle cerebral artery occlusionbrainup to 6 monthsmales

    Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans

    Experimental neurology

  2. Middle cerebral artery occlusion induces cellular senescence in rats.

    “SA-β-gal accumulation in the infarcted tissue”

    Animalsfollowing transient middle cerebral artery occlusioninfarcted brain tissuemales

    Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke

    International journal of molecular sciences

  3. Middle cerebral artery occlusion increases cellular senescence in mice.

    “Western blots analysis on the whole BM cell lysate demonstrated elevated levels of inflammatory factors (IL-6, TNF-alpha, and TLR-4) and senescence markers (p21 p16).”

    Animalsmiddle cerebral artery occlusionbone marrow

    The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changes

    Experimental neurology

More on Cellular senescence

Reactive astrogliosis

upin mice1

1 study

  1. Middle cerebral artery occlusion induces reactive astrogliosis in mice.

    “We observed that reactive astrogliosis develops more rapidly and spreads more extensively, compared to the reactive microglia response following this small infarct.”

    Animalsfollowing mild subcortical infarct (MSCI)brain

    Mild Subcortical Stroke Induces Widespread Chronic Reactive Astrogliosis That Is Largely Unaffected by Microglia and Age

    ASN neuro

Cognitive dysfunction

upin mice1

1 study

  1. Middle cerebral artery occlusion induces cognitive dysfunction in mice.

    “Experimental stroke led to consistent cognitive dysfunction and motor decline up to 6 months after ischemic injury.”

    Animalsafter middle cerebral artery occlusionbrainup to 6 monthsmales

    Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans

    Experimental neurology

DNA damage response

upin rats1

1 study

  1. Middle cerebral artery occlusion activates DNA damage response in rats.

    “significant changes in Chk1, Chk2, and LB1 at 14 days”

    Animalsat 14 days recovery following transient middle cerebral artery occlusionbrain14 daysmales

    Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke

    International journal of molecular sciences

More on DNA damage response

Senescence-associated secretory phenotype (SASP)

upin rats1

1 study

  1. Middle cerebral artery occlusion induces senescence-associated secretory phenotype (SASP) in rats.

    “significant increases in SASP markers as early as 24 h after reperfusion”

    Animals24 h after reperfusionbrain24 hmales

    Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke

    International journal of molecular sciences

More on Senescence-associated secretory phenotype (SASP)

CDKN2A

upin rats1

1 study

  1. Middle cerebral artery occlusion increases CDKN2A in rats.

    “Our results show significant increases in p16 expression, particularly in neurons and microglia/macrophages”

    Animalsfollowing transient middle cerebral artery occlusionbrainmales

    Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke

    International journal of molecular sciences

More on CDKN2A

LCP1

upin rats1

1 study

  1. Middle cerebral artery occlusion increases LCP1 in rats.

    “RT-qPCR demonstrated a marked elevation in Lcp1 mRNA and a pronounced reduction in Ccl3 in the MCAO group relative to the Sham group.”

    AnimalsMCAO versus Shamserum

    The role of SASP in ischemic stroke: a deep dive into cellular mechanisms

    Frontiers in neurology

More on LCP1

Cellular homeostasis

downin mice1

1 study

  1. Middle cerebral artery occlusion impairs cellular homeostasis in mice.

    “The signaling pathway analysis showed mitochondrial function is most affected within the bone marrow.”

    Animalsmiddle cerebral artery occlusionbone marrow

    The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changes

    Experimental neurology

More on Cellular homeostasis

Inflammation

upin mice1

1 study

  1. Middle cerebral artery occlusion increases inflammation in mice.

    “an increase in TNF-alpha and MCP-1, which are known for inducing a pro-inflammatory environment.”

    Animalsmiddle cerebral artery occlusionbone marrow

    The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changes

    Experimental neurology

More on Inflammation

Bone marrow cell count

upin mice1

1 study

  1. Middle cerebral artery occlusion increases bone marrow cell count in mice.

    “We observed a significant increase in the total cell number within the BM”

    Animalsmiddle cerebral artery occlusionbone marrow

    The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changes

    Experimental neurology

More on Bone marrow cell count

All 13