Microbial exposure

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals1

Outcomes

Cutaneous nerve area and nerve-skeleton length

upin mice1

1 study

Microbial exposure increases cutaneous nerve area and nerve-skeleton length in mice.
“Conventionalized mice exposed to microbes had greater nerve area and length than germ-free mice in both the epidermis and dermis.”
Animalsconventionalized mice compared with germ-free miceplantar skin epidermis and dermis
Automated compartment-based quantification reveals distinct patterns of cutaneous innervation with aging and microbial colonization
bioRxiv13 Oct 2026Preprint

Associations

Periodontium aging

upin humans1

1 study

Microbial exposure is associated with periodontium aging in humans.
“the cumulative effect of prolonged exposure of the periodontium to microbial challenge is, at least in part, a contributor to the effects of aging on these tissues.”
Reviewperiodontium
Aging, inflammation, immunity and periodontal disease
Periodontology 20001 Oct 2016