Methylmalonic acid

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

CCL7

upin cells1

1 study

Methylmalonic acid increases CCL7 in cells.
“Mechanistically, we demonstrated that MMA upregulates the expression of C-C motif chemokine ligand 7 (CCL7) in NPCs.”
Cellsnucleus pulposus cells
Methylmalonic Acid, an Aging-Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2-STAT3/VEGF Signaling Axis
Aging cell1 Mar 2026

Latest

3 in 12 months

Diabetes, Obesity & Metabolism29 Sep

Metformin Use Is Associated With Better Cognitive Performance in Older Adults With Type 2 Diabetes: Exploratory Analysis of Vitamin B12 and Methylmalonic Acid Pathways in NHANES 2011-2014

Cross-sectional study of 587 peopleType 2 diabetes

Paper

Aging Cell8 Mar