Methylglyoxal
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 4 more
- Animals1
Outcomes
1Mortality
no changein T. guttata1
1 study
Mortality
no changein T. guttata1
Methylglyoxal has no effect on mortality in T. guttata.
“the increased mortality, which was also absent in methylglyoxal-treated individuals, despite similar AGE accumulation.”
Animalscaptive zebra finchesdietary supplementationone year
bioRxiv (Cold Spring Harbor Laboratory)7 May 2026Preprint
Funding
1 grant since 2023National Institute on AgingUS$1.1m
Latest
12 in 12 monthsFrontiers in Nutrition
Whole wheat bread improves postprandial glucose tolerance in adults with prediabetes: a controlled-feeding randomized crossover trial with microbiome-associated variation in response
Randomised trial in 39 peoplePrediabetes
Metabolic Brain Disease
Peripheral metabolic dysfunction is associated with cognitive frailty in a mouse model of type 2 diabetes
Experiments in miceMechanisms
npj Aging
Methylglyoxal engages aging-associated mechanisms to cause filtration impairment in nephrocytes
Experiments in model organismsMechanisms
Frontiers in Cellular Neuroscience
A history of maternal separation drives systemic aging-associated signatures in middle-aged male rats
Experiments in animalsMechanisms
bioRxiv
Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches
Preprint: experiments in zebra finchesMechanisms
Physiological Genomics
Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice
Experiments in miceLipid and ceramide metabolism
Phytotherapy Research
A Novel Mechanism of Berberine Targeting EIF2AK2 Dimerization Attenuates Methylglyoxal-Induced Endothelial Senescence and Apoptosis
Experiments in animalsBerberine