Mesenchymal stem cell conditioned medium

1. Mesenchymal stem cell conditioned medium prevents femoral head collapse in mice.

   “MSC-CM suppresses bone collapse in this disorder.”

   Animalsin mouse ischemic femoral osteonecrosis modelfemoral head

   Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

   Scientific reports·9 Feb 2024

1. Mesenchymal stem cell conditioned medium increases trabecular bone volume in mice.

   “At 6 weeks post-surgery, MSC-CM increased the trabecular bone volume, thereby suppressing bone collapse.”

   Animalsin mouse ischemic femoral osteonecrosis modelfemoral head6 weeks post-surgery

   Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

   Scientific reports·9 Feb 2024

1. Mesenchymal stem cell conditioned medium decreases empty lacunae in mice.

   “It also decreased the number of empty lacunae 4 weeks after ischemia induction and promoted bone formation.”

   Animalsin mouse ischemic femoral osteonecrosis modelfemoral head4 weeks post ischemia

   Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

   Scientific reports·9 Feb 2024

More on Empty lacunae

1. Mesenchymal stem cell conditioned medium decreases senescent cells in mice.

   “MSC-CM reduced the number of senescent cells and downregulated the aforementioned senescence-related genes.”

   Animalsin mouse ischemic femoral osteonecrosis modelfemoral head

   Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse

   Scientific reports·9 Feb 2024

More on Senescent cells