Matrix metalloproteinase-10
Matrix metalloproteinase-10 has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, May 9, 2023: “Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells”.
1 paper studies it3 findingsUpdated
- 1 lab in 1 country
- Funders: Centro de Investigación Biomédica en Red de Cáncer and 7 more
- Animals1
What did studies of Matrix metalloproteinase-10 find?
3Studies of Matrix metalloproteinase-10 measured 3 outcomes; the most studied are DNA damage response (1 study), muscular dystrophy (1) and cellular senescence (1).
DNA damage response
downin human cells1
1 study
DNA damage response
downin human cells1
Matrix metalloproteinase-10 decreases DNA damage response in human cells.
“MMP-10 conserves its protective effect in the satellite cell-derived myoblasts isolated from a Duchenne muscular dystrophy patient by decreasing the accumulation of damaged DNA.”
Cellsin satellite cell-derived myoblasts isolated from a Duchenne muscular dystrophy patient
Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
Frontiers in cell and developmental biology
Muscular dystrophy
downin mice1
1 study
Muscular dystrophy
downin mice1
Matrix metalloproteinase-10 protects against muscular dystrophy in mice.
“Systemic treatment of mdx dystrophic mice with MMP-10 prevents the muscle deterioration phenotype and reduces cellular damage in the satellite cells”
Animalsin mdx dystrophic miceskeletal muscle
Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
Frontiers in cell and developmental biology
Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
Matrix metalloproteinase-10 inhibits cellular senescence in mouse cells.
“reduction of MMP-10 levels in young satellite cells from wild type animals induces a senescence response, while addition of the protease delays this program.”
Cellsunder proliferative pressure
Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
Frontiers in cell and developmental biology