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Lxr agonist

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Animals1

Outcomes

1

Lifespan

upin mice1

1 study

  1. Lxr agonist extends lifespan in mice.

    “Daily treatment of the npc1(-/-) mice with an LXR agonist or administration of a single dose of cyclodextrin, with or without the neurosteroid allopregnanolone, significantly slowed neurodegeneration and increased the lifespan of these animals.”

    Animalsin npc1(-/-) mice

    Genetic variations and treatments that affect the lifespan of the NPC1 mouse

    Journal of lipid research12 Dec 2007

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