Low educational level

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 3 countries

1 of 2 findings with company ties

Humans2

Associations

Cognitive decline

downin humans1OR 0.08

1 study

Low educational level lowers the risk of cognitive decline in humans (OR=0.08, p<0.001).
“The predictors of cognitive decline were low educational level (OR=0.08, p <0.001)”
Humansin multivariate logistic regression
Modifiable Risk Factors and Their Potential Impact on Conversion from Normal Cognition and MCI to Dementia: Findings from a Cohort Study of Brazilian Older Adults
AAIC 2025 abstract23 Dec 2025

Intrinsic capacity impairment

upin humans1OR 3.04

1 study

Low educational level is associated with intrinsic capacity impairment in humans (OR 3.04; 95% CI 1.4–6.7).
“factors associated with IC impairment included low educational level [odds ratio (OR) 3.04; 95% confidence interval (CI): 1.4-6.7]”
HumansRetired Cameroonians; adjusted for age and sex
Prevalence of intrinsic capacity impairment and associated factors among retired older people in Cameroon
BMC geriatrics6 Oct 2025