Low-age diet

1. Low-age diet has no effect on disposition index in humans (P > 0.05).

   “However, DI did not differ between groups (P > 0.05).”

   Human trialprediabetesisocaloric, macronutrient-matched and low - heat cooking≤ 16 mg/day4-weekn = 32

   Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on Disposition index

1. Low-age diet decreases liver insulin resistance in humans (P = 0.007).

   “a significant decrease of LIR level not MIR was detected (P = 0.007) only in low-dAGE group”

   Human trialprediabetesisocaloric, macronutrient-matched and low - heat cooking≤ 16 mg/day4-weekn = 32

   Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on Liver insulin resistance

1. Low-age diet decreases C-reactive protein in humans (P = 0.002).

   “lower CRP (P = 0.002) and skin AGEs (P =0.041) vs. controls”

   Human trialprediabetesisocaloric, macronutrient-matched and low - heat cooking≤ 16 mg/day4-weekn = 32

   Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on C-reactive protein

1. Low-age diet increases Matsuda Index in humans (P = 0.006).

   “improved Matsuda index (P = 0.006)”

   Human trialprediabetesisocaloric, macronutrient-matched and low - heat cooking≤ 16 mg/day4-weekn = 32

   Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on Matsuda Index

1. Low-age diet decreases visceral adipose tissue in humans (P = 0.028).

   “The low-dAGE group showed greater VAT reduction (P = 0.028)”

   Human trialprediabetesisocaloric, macronutrient-matched and low - heat cooking≤ 16 mg/day4-weekn = 32

   Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

1. Low-age diet prevents kidney fibrosis in mice.

   “did not have increased oxidant stress or cardiac or kidney fibrosis with aging”

   Animalswith aging

   Advanced glycation end product homeostasis: exogenous oxidants and innate defenses

   Annals of the New York Academy of Sciences·1 Apr 2008

1. Low-age diet prevents cardiac fibrosis in mice.

   “did not have increased oxidant stress or cardiac or kidney fibrosis with aging”

   Animalswith aging

   Advanced glycation end product homeostasis: exogenous oxidants and innate defenses

   Annals of the New York Academy of Sciences·1 Apr 2008

1. Low-age diet decreases advanced glycation end products in mice (approximately 50% lowered content).

   “Mice fed a diet with a lowered (approximately 50%) content of AGEs or a typical calorie-restricted (CR) diet, accumulated a smaller amount of AGEs”

   Animalswith aging

   Advanced glycation end product homeostasis: exogenous oxidants and innate defenses

   Annals of the New York Academy of Sciences·1 Apr 2008

More on Advanced glycation end products

1. Low-age diet decreases 8-isoprostane in mice.

   “higher than baseline levels of tissue AGER1 and glutathione/oxidized glutathione and reduced plasma 8-isoprostanes and tissue RAGE and p66(shc) levels”

   Animalslife-long exposuremales

   Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression

   The American journal of pathology·1 Jun 2007

More on 8-isoprostane

1. Low-age diet decreases glomerulosclerosis in mice.

   “amelioration of insulin resistance, albuminuria, and glomerulosclerosis.”

   Animalslife-long exposuremales

   Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression

   The American journal of pathology·1 Jun 2007

More on Glomerulosclerosis