Lidocaine

  • 1 lab
  • Animals1

Outcomes

6

Ctnnb1 expression

upin rats1

1 study
  1. Lidocaine increases Ctnnb1 expression in rats.

    “upregulated Wnt1 and β-catenin expression”

    Animalsisoflurane-induced cognitive dysfunction

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

More on Ctnnb1 expression

Wnt1 expression

upin rats1

1 study
  1. Lidocaine increases Wnt1 expression in rats.

    “upregulated Wnt1 and β-catenin expression”

    Animalsisoflurane-induced cognitive dysfunction

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

More on Wnt1 expression

Mpo expression

downin rats1

1 study
  1. Lidocaine decreases Mpo expression in rats.

    “reduced MPO expression and upregulated Wnt1 and β-catenin expression”

    Animalsisoflurane-induced cognitive dysfunctionbrain

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

More on Mpo expression

M1-to-M2 macrophage polarization

upin rats1

1 study
  1. Lidocaine increases M1-to-M2 macrophage polarization in rats.

    “promoted the conversion of M1 macrophages to M2 macrophages in serum”

    Animalsisoflurane-induced cognitive dysfunctionserum

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

Neuronal apoptosis rate

downin rats1

1 study
  1. Lidocaine decreases neuronal apoptosis rate in rats.

    “reduced the apoptosis rate and serum IL-1β and TNF-α levels”

    Animalsisoflurane-induced cognitive dysfunctionbrain

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

More on Neuronal apoptosis rate

Cognitive and learning function

upin rats1

1 study
  1. Lidocaine improves cognitive and learning function in rats.

    “LD increased the cognitive index, novel arm dwell time, and distance traveled in the novel arm in rats”

    Animalsisoflurane-induced cognitive dysfunction

    Effects of lidocaine on macrophage polarization in aged rats with cognitive dysfunction induced by isoflurane anesthesia

    Chinese Journal of Gerontology8 Oct 2026

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