LET-7B-5P mimic + MIR-100-5P mimic

1 paper2 findings

1 lab in 1 country

Funders: Canadian Institutes of Health Research and 1 more

Humans1

Outcomes

2

TEK

upin human cells1

1 study

LET-7B-5P mimic + MIR-100-5P mimic increases TEK in human cells.
“co-delivery of both miRNAs enhanced suppression of pro-inflammatory mediators, reduced senescence-associated p16 expression and upregulated TIE2 mRNA”
Cellsco-delivery of both miRNAs in IVD cellsintervertebral disc
Beyond miRNA Cargo Profiles: Anti-Inflammatory Roles of Extracellular Vesicle-Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing
Journal of extracellular biology7 Apr 2026

CDKN2A

downin human cells1

1 study

LET-7B-5P mimic + MIR-100-5P mimic decreases CDKN2A in human cells.
“co-delivery of both miRNAs enhanced suppression of pro-inflammatory mediators, reduced senescence-associated p16 expression and upregulated TIE2 mRNA”
Cellsco-delivery of both miRNAs in IVD cellsintervertebral disc
Beyond miRNA Cargo Profiles: Anti-Inflammatory Roles of Extracellular Vesicle-Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing
Journal of extracellular biology7 Apr 2026

Latest

1 in 12 months

Journal of Extracellular Biology9 Apr

Beyond miRNA Cargo Profiles: Anti-Inflammatory Roles of Extracellular Vesicle-Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing

Study in peopleInflammation