Lactoferrin

1. Lactoferrin has no effect on adverse events in humans.

   “Adverse events were comparable between the groups and no adverse drug reactions were observed.”

   Human trialhealthy Japanese postmenopausal women; compared with placebobovine300 mg/day12 weeksfemales

   Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial

   Nutrients·27 Sep 2026

1. Lactoferrin decreases urinary deoxypyridinoline in humans.

   “In addition, the urinary deoxypyridinoline levels were significantly lower in the LF group than in the placebo group.”

   Human trialhealthy Japanese postmenopausal women; exploratory analysis; compared with placebobovine300 mg/day12 weeksfemalesn = 72

   Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial

   Nutrients·27 Sep 2026

More on Urinary deoxypyridinoline

1. Lactoferrin increases immunoglobulin G1 in humans.

   “The vaginal immunoglobulin G1 levels were significantly higher in the LF group than in the placebo group.”

   Human trialhealthy Japanese postmenopausal women; exploratory analysis; compared with placebobovinevagina300 mg/day12 weeksfemalesn = 72

   Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial

   Nutrients·27 Sep 2026

More on Immunoglobulin G1

1. Lactoferrin decreases Gardnerella/Bacteroides Nugent sub-score in humans.

   “The Gardnerella/Bacteroides Nugent sub-score was significantly lower in the LF group than in the placebo group.”

   Human trialhealthy Japanese postmenopausal women; secondary analysis; compared with placebobovinevagina300 mg/day12 weeksfemalesn = 72

   Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial

   Nutrients·27 Sep 2026

More on Gardnerella/Bacteroides Nugent sub-score

1. Lactoferrin has no effect on Nugent score in humans.

   “Although the Nugent score was lower in the LF group, the difference was not significant.”

   Human trialhealthy Japanese postmenopausal women; compared with placebobovinevagina300 mg/day12 weeksfemalesn = 72

   Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial

   Nutrients·27 Sep 2026

More on Nugent score

1. Lactoferrin inhibits oxidative stress and ROS signalling.

   “Anti-aging interventions of LF have proven to be safe and effective for various pharmacological activities, such as anti-oxidation, anti-cellular senescence, anti-inflammation, and anti-carcinogenic.”

   Review

   The effect of lactoferrin in aging: role and potential

   Food & function·24 Jan 2022

More on Oxidative stress and ROS signalling

1. Lactoferrin inhibits inflammation.

   “Anti-aging interventions of LF have proven to be safe and effective for various pharmacological activities, such as anti-oxidation, anti-cellular senescence, anti-inflammation, and anti-carcinogenic.”

   Review

   The effect of lactoferrin in aging: role and potential

   Food & function·24 Jan 2022

More on Inflammation

1. Lactoferrin inhibits cellular senescence.

   “Anti-aging interventions of LF have proven to be safe and effective for various pharmacological activities, such as anti-oxidation, anti-cellular senescence, anti-inflammation, and anti-carcinogenic.”

   Review

   The effect of lactoferrin in aging: role and potential

   Food & function·24 Jan 2022

More on Cellular senescence