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KI26894

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Japan Society for the Promotion of Science and 4 more
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

2

Weakness

downin mice1

1 study

  1. KI26894 decreases weakness in mice.

    “Oral administration of Ki26894, a small-molecule inhibitor of type I receptors for these TGF-βs, restored muscle atrophy and weakness in α-Klotho (-/-) mice and in elderly wild-type mice”

    Animalsin α-Klotho (-/-) mice and in elderly wild-type mice

    Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia

    The American journal of pathology10 Feb 2023

Muscle atrophy

downin mice1

1 study

  1. KI26894 decreases muscle atrophy in mice.

    “Oral administration of Ki26894, a small-molecule inhibitor of type I receptors for these TGF-βs, restored muscle atrophy and weakness in α-Klotho (-/-) mice and in elderly wild-type mice”

    Animalsin α-Klotho (-/-) mice and in elderly wild-type mice

    Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia

    The American journal of pathology10 Feb 2023

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