Jnk inhibitor

1. Jnk inhibitor has no effect on joint architecture in mice.

   “without showing any structural improvements in the joint architecture”

   Animalsin PTOA mice

   Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain

   Arthritis research & therapy·Feb 17, 2024

1. Jnk inhibitor improves gait parameters in mice.

   “Jnk inhibition and lowered CCL2 and 7 are sufficient to significantly improve the gait parameters in treated PTOA mice demonstrating reduced OA-associated pain.”

   Animalsin treated PTOA mice

   Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain

   Arthritis research & therapy·Feb 17, 2024

1. Jnk inhibitor decreases Ccl7 in mice.

   “Modulation of Jnk signaling led to attenuation of inflammatory cytokines CCL2 and CCL7”

   Animalsin PTOA mice

   Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain

   Arthritis research & therapy·Feb 17, 2024

More on Ccl7

1. Jnk inhibitor decreases CCL2 in mice.

   “Modulation of Jnk signaling led to attenuation of inflammatory cytokines CCL2 and CCL7”

   Animalsin PTOA mice

   Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain

   Arthritis research & therapy·Feb 17, 2024

More on CCL2

1. Jnk inhibitor has no effect on lifespan in A. stephensi.

   “SMI-treated mosquitoes exhibited no difference in lifespan compared to controls”

   Model organisms

   Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection

   PLoS pathogens·Nov 29, 2018

1. Jnk inhibitor decreases Plasmodium falciparum infection in A. stephensi.

   “MKP4 overexpression and SMI treatment reduced the proportion of P. falciparum-infected mosquitoes and decreased oocyst loads relative to controls.”

   Model organisms

   Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection

   PLoS pathogens·Nov 29, 2018

More on Plasmodium falciparum infection