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MKP4

Gene

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab
  • Model organisms1

Effects

2

Lifespan

upin A. stephensi1

1 study

  1. MKP4 extends lifespan in A. stephensi.

    “whereas genetically manipulated mosquitoes exhibited extended longevity.”

    Model organismsmidgut-specific MKP4 overexpressionmidgut

    Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection

    PLoS pathogens

Plasmodium falciparum infection

downin A. stephensi1

1 study

  1. MKP4 decreases Plasmodium falciparum infection in A. stephensi.

    “MKP4 overexpression and SMI treatment reduced the proportion of P. falciparum-infected mosquitoes and decreased oocyst loads relative to controls.”

    Model organismsmidgut-specific MKP4 overexpressionmidgut

    Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection

    PLoS pathogens

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