1 paper1 finding
Hormone replacement therapy
upin humans1OR 1.26
Hormone replacement therapy raises the risk of anterior cruciate ligament tear in humans (OR 1.26, 95% CI 1.02-1.55).
“women in the supplemental estrogen-exposed group had a significantly higher risk of any ACL tear (OR: 1.26, 95% CI: 1.02-1.55)”
Humanscontrolling for age, comorbidities, and perimenopausal or menopausal statusfemalesn = 384,582
Hormone therapy linked to knee ligament tear risk in midlife women
JB & JS open access11 Oct 2026
Chinese University of Hong Kong
1 trialPhase 260 people
Andrews Research & Education Foundation
1 trialPhase 224 people
1 trialPhase 26 people
1 trialPhase 14 people
Women taking estrogen-containing hormone therapy had higher odds of knee ligament tears than matched controls, with an odds ratio of 1.26.Women taking estrogen-containing hormone therapy had higher odds of knee ligament tears than matched controls, with an odds ratio of 1.26.